On stage 6, with three kilometres remaining, two spectators ran onto the road and attempted to stretch tape across the path of breakaway riders, according to race reports. One of them, a man, hit Taco van der Hoorn with the tape, forcing him to brake and duck, as reported by race officials. The incident disrupted both the breakaway and the peloton, according to Eurosport commentator Rob Hatch.
Accounts of the incident vary: some reports describe a single spectator jumping into the road and waving his arms, at times appearing to make contact with riders, while others detail two spectators using tape. A person behind the man appeared to be filming, according to eyewitness accounts. Before the stage, Uno-X's Johannes Kulset was in fifth place overall, according to race standings.
Stage 14 brought further disruption when a crash occurred about 23 kilometres from the finish on a wet cobbled corner, according to race reports. Isaac del Toro, Simon Yates, and Richard Carapaz avoided the incident, but Primož Roglič and Juan Ayuso were caught behind and lost 48 seconds, as reported by race officials. Egan Bernal was also in the group that lost time, according to race reports.
After the stage, Ayuso fell to third overall, his deficit to Del Toro increasing from 38 seconds to 1:26, according to official results. Roglič retained fifth place but fell to 2:23 behind the pink jersey, while Bernal dropped to ninth, 3:38 back, only seven seconds ahead of teammate Thymen Arensman, as per race standings. The opening day of the Giro had already been marred by crashes.
Mikel Landa crashed out and fractured a vertebra, according to a Soudal Quick-Step statement. Jay Vine was involved in the same crash but remounted and continued, according to race reports. Geoffrey Bouchard crashed on the same corner and was forced to abandon, suffering a fractured right collarbone and fractures of the transverse processes of the first three lumbar vertebrae, his team Decathlon AG2R La Mondiale confirmed.
In the final kilometre of stage 1, a mass pile-up occurred when Tord Gudmestad swerved to avoid metal feet at the bottom of barriers, bringing down around a dozen riders including Dylan Groenewegen and Kaden Groves, according to race reports. Groves sustained abrasions to both shoulders, his calf and elbow but was expected to start stage 2, Alpecin-Premier Tech stated. Groenewegen appeared to nurse a hurt wrist but was ready to continue, according to Unibet Rose Rockets.
Erlend Blikra and Matteo Moschetti also crashed, according to race reports. No riders lost time on GC because the crash occurred within the final 5km, as per race regulations. Other incidents included Dion Smith having a near-miss after being clipped by a goat, and on stage 5, a man stepping toward the centre of a roundabout as the peloton approached, nearly causing a crash, according to race reports.
Jai Hindley, a top GC contender, had a major incident in the first week, according to race reports.