According to Daily Express - Showbiz, Margolyes described having a chronic shoulder injury that prevents her from putting on a bra without assistance. She said the injury was caused by falling incorrectly during a six-month play about 40 years ago. Margolyes also revealed she has a weak pelvic floor and experiences incontinence, advising others to do pelvic floor exercises.
The actress had an aortic valve replacement in 2023 and has spinal stenosis, though the specific impact on her daily life is not detailed.