In her opening match, Raducanu will face either Sierra Solana or a qualifier. She is likely to face reigning French Open champion Coco Gauff in the third round, with Mirra Andreeva as a potential quarter-final opponent. World No. 1 Aryna Sabalenka is on the same half of the draw. Raducanu reached the fourth round of the Italian Open last year, where Gauff ended her campaign. It remains to be seen whether her right hand injury will fully recover during the tournament.
In the men's draw, Jannik Sinner headlines after winning the Madrid Open dropping just one set. Sinner has never won the Italian Open and will open against either Sebastian Ofner or Alex Michelsen in round two. Novak Djokovic is preparing for his first clay tournament of the season, having been absent since Indian Wells. Djokovic is on the opposite half of the draw and will face Marton Fucsovics or a qualifier. His form after such a long absence is uncertain.
Jack Draper is skipping the Italian Open and has confirmed he will not participate in this month's French Open. Draper has competed in just one match on clay this year and is aiming to return from injury in time for the grass swing. The exact timeline for his return has not been announced.